I am the Head of the School of Life Sciences at The University of Nottingham (since Feb 1st, 2018), Chair in Evolutionary Biology, and principal investigator of this research group. I am also an elected Fellow of the American Academy of Microbiology since 2015 and an elected Fellow of the Linnean Society since 2016. In 2020 I was elected President of the Society for Molecular Biology and Evolution, a position I will take up for the duration of 2022.
My surname sounds like “Mack-And-Ernie”. I thought I’d mention it, since many people ask.
My BSc and PhD were awarded by University College Galway, where I studied from 1987 until 1994. Subsequently I worked as a post-doc at the National Diagnostics Centre in Galway and in the Department of Zoology at The Natural History Museum, London. In 1999 I set up the bioinformatics research group at NUI Maynooth and became the director of the Genetics and Bioinformatics degree course. For the academic year 2012-2013, I took a sabbatical at the Center for Communicable Disease Dynamics at Harvard University, USA. In 2015 I moved my research to The University of Manchester to take up a chair in evolutionary biology. In 2016 I was appointed as the director of the research domain of “Evolution, Systems and Genomics” in the Faculty of Biology, Medicine and Health at the University of Manchester. In 2018, I became the Head of the School of Life Sciences at the University of Nottingham and moved my research group to the Life Sciences Building on University Campus.
In 2015, I was recognised by the Irish government with a conference ambassador award by the Minister for Tourism. I was elected secretary of the Society for Molecular Biology and Evolution for the period 2013-2017. In 2013, I was awarded a DSc by the National University of Ireland for a thesis entitled “Studies on the evolution of genes and genomes”. I served as an Associate Editor of Molecular Biology and Evolution from 2009 until I stepped down in 2018, and as an Associate Editor of the Journal of Experimental Zoology since 2011. I am also a scientific associate of The Natural History Museum, London.
Domingo-Sananes, M.R. and McInerney, J.O. (2021) Mechanisms That Shape Microbial Pangenomes. Trends in Microbiology https://doi.org/10.1016/j.tim.2020.12.004
Whelan, F.J. Rusilowicz, M. and McInerney J.O. (2020) Coinfinder: detecting significant associations and dissociations in pangenomes. Microbial Genomics. DOI 10.1099/mgen.0.000338
McInerney, J.O., McNally, A and O’Connell, M.J. (2017) Why Prokaryotes have Pangenomes. Nature Microbiology 2, 17040. https://www.nature.com/articles/nmicrobiol201740
McInerney, J.O. and O’Connell, M.J. (2017) Minding the gaps in cellular evolution. Nature 541, 297–299 doi:10.1038/nature21113
McInerney, J.O. (2016) Evolution: A four billion year old metabolism. Nature Microbiology. 1, Art. No. 16139. https://www.nature.com/articles/nmicrobiol2016139
Ku, C., Nelson-Sathi, S., Roettger, M., Sousa, F.L., Lockhart, P., Bryant, D., Hazkani-Covo,E., McInerney, J.O., Landan, G., and Martin, W.F. (2015) Endosymbiotic origin and differential loss of eukaryotic genes Nature. 524, 427–432. doi:10.1038/nature14963
Nelson-Sathi, et al., (2015). Origins of major archaeal clades correspond to gene acquisitions from bacteria. Nature doi:10.1038/nature13805. [pdf]
McInerney, J.O. and O’Connell, M.J. (2014) Evolutionary developmental biology: Ghost locus appears. Nature 514, 570–571. doi:10.1038/514570a. [pdf]
McInerney, et al., (2014). The hybrid nature of the Eukaryota and a consilient view of life on Earth. Nature Reviews Microbiology doi:10.1038/nrmicro3271.[pdf]
Liu et al., (2014) Population Genomics Reveal Recent Speciation and Rapid Evolutionary Adaptation in Polar Bears. Cell , 157(4) 785 – 794. doi:10.1016/j.cell.2014.03.054 [pdf]
Alvarez-Ponce, et al., (2013). Gene similarity networks provide new tools for understanding eukaryote origins and evolution.Proceedings of the National Academy of Sciences USA doi: 10.1073/pnas.1211371110.[pdf]
Nelson-Sathi, et al., (2012) Acquisition of 1,000 eubacterial genes physiologically transformed a methanogen at the origin of Haloarchaea. Proceedings of the National Academy of Sciences USA. 109 (50) 20537-20542 doi: 10.1073/pnas.1209119109.[pdf]
Bapteste et al., (2012). Evolutionary analyses of non-genealogical bonds produced by introgressive descent. Proceedings of the National Academy of Sciences, USA. 109:(45) 18266-18272 doi:10.1073/pnas.1206541109.
Cotton, J.A., and McInerney, J.O. (2010) Eukaryotic genes of archaebacterial origin are more important than the more numerous eubacterial genes, irrespective of function. Proceedings of the National Academy of Sciences, USA 107:40 17252-17255. [link]
McInerney, J.O. and Pisani, D (2007) Genetics: Paradigm for Life. Science 318:1390-1391. [link]
Kinsella et al., (2003). Fatty acid biosynthesis in Mycobacterium tuberculosis: Lateral gene transfer, adaptive evolution and gene duplication. Proceedings of the National Academy of Sciences, USA, 100, 10320-10325. [link]
McInerney, J.O. (1998). Replicational and Transcriptional Selection on Codon Usage in Borrelia burgdorferi. Proceedings of the National Academy of Sciences, USA: 95 10698-10703. [link]
You can find more of our publications by clicking the Papers tab at the top of this page.
– Horizontal Gene Transfer
– Eukaryote origins and early evolution
– Network analyses of evolution
– Synonymous Codon Usage
– Phylogenetic Supertrees
– Adaptive evolution
Major Software Projects:
Coinfinder: detecting significant associations and dissociations in pangenomes
TIGER: Tree-Independent Generation of Evolutionary Rates.
TOPD/FMTS: Software to Compare Phylogenetic Trees (Developed by Pere Puigbo, during his stay in the group).
MultiPhyl: Phylogenetic Supercomputer.
Modelgenerator: Selection of Amino Acid Substitution Matrices.
DPRml: Distributed Phylogeny Reconstruction by Maximum Likelihood.
CLANN: Investigating Phylogenetic Information Through Supertree Analysis.
Crann: A Program for Detecting Adaptive Evolution in Protein-Coding DNA Sequences.
GCUA: General Codon Usage Analysis.