Address

School of Life Sciences, University Park,

Contact Information

Research Interests

  • Genomics
  • Pangenomes

Dr. Maria Rosa Domingo Sananes

María completed her Degree in Biology at the Universidad de Los Andes in Mérida, Venezuela followed by a MPhil in Computational Biology at the University of Cambridge. During her DPhil at the University of Oxford she worked on mathematical modelling of cell cycle control in eukaryotes. Since then, she has been interested in combining evolutionary and systems biology approaches to understand diverse aspects of living systems, such as cell differentiation in trypanosomes (as a CIIE Fellow at the University of Edinburgh, UK) and how yeast cells recover from lack of control of mitotic entry during experimental evolution (as a Postdoc at the Institute for Genetics and Development in Rennes, France). She is currently interested in the mechanisms that result in gene content diversity and pangenomes, and in the evolution of regulatory networks, in particular cell cycle control in eukaryotes.

Selected publications

Callens C, Coelho NC, Miller AW, Domingo Sananes MR, Dunham MJ, Denoual M, Coudreuse D. (2017) A multiplex culture system for the long-term growth of fission yeast cells. Yeast. 34:343-355.

Domingo-Sananes MR, Szöőr B, Ferguson MA, Urbaniak MD, Matthews KR. (2015) Molecular control of irreversible bistability during trypanosome developmental commitment. The Journal of Cell Biology. 211(2):455-68.

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María completed her Degree in Biology at the Universidad de Los Andes in Mérida, Venezuela followed by a MPhil in Computational Biology at the University of Cambridge. During her DPhil at the University of Oxford she worked on mathematical modelling of cell cycle control in eukaryotes. Since then, she has been interested in combining evolutionary and systems biology approaches to understand diverse aspects of living systems, such as cell differentiation in trypanosomes (as a CIIE Fellow at the University of Edinburgh, UK) and how yeast cells recover from lack of control of mitotic entry during experimental evolution (as a Postdoc at the Institute for Genetics and Development in Rennes, France). She is currently interested in the mechanisms that result in gene content diversity and pangenomes, and in the evolution of regulatory networks, in particular cell cycle control in eukaryotes.

Selected publications

Callens C, Coelho NC, Miller AW, Domingo Sananes MR, Dunham MJ, Denoual M, Coudreuse D. (2017) A multiplex culture system for the long-term growth of fission yeast cells. Yeast. 34:343-355.

Domingo-Sananes MR, Szöőr B, Ferguson MA, Urbaniak MD, Matthews KR. (2015) Molecular control of irreversible bistability during trypanosome developmental commitment. The Journal of Cell Biology. 211(2):455-68.

Lu LX, Domingo-Sananes MR, Huzarska M, Novak B, Gould KL. (2012) Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches. Proceedings of the National Academy of Sciences USA. 109(25):9899-904.

Domingo-Sananes MR, Kapuy O, Hunt T, Novak B. (2011) Switches and Latches: a biochemical tug-of-war between the kinases and phosphatases that control mitosis. Philosophical Transactions of the Royal Society B Biological Sciences. 366(1584):3584-94.

Krasinska L, Domingo-Sananes MR, Kapuy O, Parisis N, Harker B, Moorhead G, Rossignol M, Novak B and Fisher D. (2011) Protein phosphatase 2A controls the order and dynamics of cell cycle transitions. Molecular Cell. 44(3):437-50.

Domingo-Sananes MR, Novak B. (2010) Different effects of redundant feedback loops on a bistable switch. Chaos. 20(4):045120.