Welcome to the website of the McInerney laboratory at the University of Nottingham

Welcome to the website of James McInerney's lab at the University of Nottingham.

The McInerney Research group at School of Life Sciences, University of Nottingham is an evolutionary biology group that is interested in answering fundamental questions about the evolution of life on the planet.

The principal approach that we take is computational, and the data includes genomes, proteomes, metabolomic data and simulated data.

We are living in the golden age of data and in particular genomic data is being generated at a faster rate than most could have imagined a few years ago. In this research group we are using high performance computing, comparative genomics, phylogenetics, statistics, simulations and machine learning in order to turn data into knowledge.

The elements of life – protein domains, genes, gene clusters, genomes, communities, the global ecosystem – are inextricably linked in a complex, dynamic network and we are working to uncover this network.

Selected Recent Papers

Why Prokaryotes have Pangenomes. Nature Microbiology (2017) 2, 17040.

McInerney, J.O., McNally, A and O’Connell, M.J.

Minding the gaps in cellular evolution. Nature (2017) 541, 297–299.

McInerney, J.O. and O’Connell, M.J.

Combined analysis of variation in core, accessory and regulatory genome regions provides a super-resolution view into the evolution of bacterial populations. PLoS Genet (2016) 12(9): e1006280

McNally, A., Oren, Y., Kelly, D., Pascoe, B., Dunn, S., Sreecharan, T., Vehkala, M., Välimäki, N., Prentice, M.B., Ashour, A., Avram, O., Pupko, T., Dobrindt, U., Literak, I., Guenther, S., Schaufler, K., Wieler, L.H., Zhiyong, Z., Sheppard, S.K., McInerney, J.O. and Corander, J.

Evolution: A four billion year old metabolism. Nature Microbiology (2016) 1, 16139.

McInerney, J.O.

Origins of major archaeal clades correspond to gene acquisitions from bacteria. Nature (2015) 517, 77–80.

Nelson-Sathi S., Sousa F.L., Roettger M., Lozada-Chávez N., Thiergart T., Janssen A., Bryant D., Landan G., Schönheit P., Siebers B., McInerney J.O., Martin W.F.

Endosymbiotic origin and differential loss of eukaryotic genes. Nature (2015) 524, 427–432.

Ku, C.,Nelson-Sathi, S., Roettger, M., Sousa, F.L. Lockhart, P.J., Bryant, D., Hazkani-Covo, E., McInerney, J.O., Landan, G. and Martin, W.F.

Gene similarity networks provide new tools for understanding eukaryote origins and evolution. Proceedings of the National Academy of Sciences USA (2013) 110(17): E1594-603.

Alvarez-Ponce, D., Lopez, P., Bapteste, E. and McInerney, J.O.

PhD Position Available

Self-funded students only. 

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